Challenges to Mediation Analysis From Experimental Designs

Analysis of MultiFactor Experimental Designs

Within-Subject Mediation Analysis in AB/BA Crossover Designs.

Crossover trials are widely used to assess the effect of a reversible exposure on an outcome of interest. To gain further insight into the underlying mechanisms of this effect, researchers may be interested in exploring whether or not it runs through a specific intermediate variable: the mediator. Mediation analysis in crossover designs has received scant attention so far and is mostly confined...

Experimental Analysis of the Mediation Hierarchy Theory

The combination of autonomous and supervisory con trol methods should permit the creation of a semi autonomous system capable of completing all feasible tasks We have developed the Multiple Agent Super visory Control MASC system based upon the medi ation hierarchy theory to create such a system We brie y describe this system and the mediation hierar chy The purpose of this paper is to review th...

Statistical analysis of experimental designs applied to biological assays

Bioassays are methods employed to estimate the effect of a given substance in living matter, and therefore they are frequently used in the pharmaceutical industry. The experimental design of bioassays has to take into account the intrinsic variability in the biological test units and other factors as operators, day variation, batch variation, etc. Thus, statistical models employed to analyse bi...

Organelle proteomics experimental designs and analysis.

In biology, localisation is function: knowledge of the localisation of proteins is of paramount importance to assess and study their function. This supports the need for reliable protein sub-cellular localisation assignment. Concomitant with recent technological advances in organelle proteomics, there is a requirement for more rigorous experimental and analysis design planning and description. ...